By Professor Dr. W. E. Adam, Professor Dr. K. Alexander, Dr. F. Bitter, Dr. F. J. Bonte, Dr. L. M. Buja, Professor Dr. G. Buttermann, Professor Dr. K.-D. Ebel, Dr. H.-J. Engel, A. Kuruc, Dr. S. E. Lewis, Professor Dr. P. Lichtlen, Dr. J. A. Markisz, Professo
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Extra resources for Nuklearmedizin / Nuclear Medicine: Teil 3 Diagnostik II Pädiatrische Nuklearmedizin / Part 3 Diagnostic II Pediatric Nuclear Medicine
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Total transit time to peak concentration (TTp) of RV and LVvs. heart rate (HR) (radionuclide bot, I lus, n = 200). Mean total transit times to peak concen~-----------------~i tration in the LV vary significantly with all heart 2" p < 0,001 rates between 50-89 beats/min and 90-109 beats/min. For the RV there is a significant difference between the mean TTp of 50-59 beats/min and 90-109 beats/ min. ---,50-59 60-69 70-79 80- 89 90- 99 HR Fig. 6a. Number of heart cycles (Cy) to peak concentration of RV and LV vs.
13a-d Coronary Artery Disease 25 diastolic volume increases much more than stroke volume, so that the global ejection fraction decreases during stress. Most importantly, however, in both groups end-systolic volume increased, in contrast to a control group of normal individuals (JONES et al. 1978). In patients in whom the EF does not change or decreases under stress, the resting EF is frequently normal, i. , does not exclude significant coronary artery disease. Regional left ventricular function at rest may also be normal or may already show circumscribed motion and ejection disorders.
Correspondingly, these regions are" noisy," poorly delineated, and difficult to separate from surrounding areas, and their function is not easily evaluated. However, it is precisely these regions that are the most important in regional diagnosis. Furthermore, by concentrating on only the two endpoints of the cardiac cycle one loses all information about what occurs throughout the entire period of ventricular contraction or relaxation (SCHAD and NICKEL 1978). To overcome these drawbacks, all regional changes during an entire cardiac phase or part of that phase can be fitted (via least squares) to a given mathematical function so that an automatic smoothing of the data occurs.